Advanced Organic Synthesis

We not only master HPAPI handlingchiral technologiespreparative chromatography and hazardous chemistry, but also a unique know-how for conducting certain demanding reactionsused in organic synthesis that yield pure organic compounds in a cost-effective and time efficient manner:

Cryogenic reactions

Friedel Craft reactions

Micro-reaction technologies

Transition metal catalysis

Hydrogenation

Halogenation

Biocatalysis

Organometallic chemistry

Heterocyclic chemistry

Mitsunobu reactions

And many other reactions

Cryogenic reactions

We pioneered low temperature reactions at industrial scale for more than 30 years and are equipped for -80 °C reactions at industrial scale.

Ideal to improve selectivity or to use highly reactive compounds such has organolithium reagents, we have also developed a unique set of two reactors (3,000 L and 4,000 L) in series for coupling two low temperature reactions.

More information on cryogenic reactions

Friedel-Crafts reactions

We have the world’s largest cGMP capacity for Friedel-Crafts acylation, alkylation and hydroalkylation with a 6,000 L reactor and more than 30 tons of AlCl3 storage.

We reduce the environmental impact of Friedel-Crafts reactions by supplying the aluminum hydroxide by-product that we generate to water treatment companies.

Micro-reaction technology

We are highly active in developing reactions based on micro-reactor technology, especially for energetic or safety critical reactions such as glycerine nitration.

Transition Metal-Catalyzed reactions

We master catalyzed C-C and C-N cross coupling reactions such as Suzuki, Heck, Sonogashira, and Buchwald reactions from pilot to industrial scale.

Our ability to prepare aryl and vinyl triflates, chlorides and bromides as well as boronic acid derivatives in-house, gives us access to a wide selection of substrates at low cost for transition metal-catalyzed cross coupling reactions.

In addition, our ability to handle carbon monoxide from gram to hundreds of kilogram scale gives us access to a Pd-catalyzed carbonylation reactions.

Hydrogenation reactions

We are equipped with large-scale hydrogenation capabilities that can be used in both asymmetric and standard version, combined with H-cube screening technology in order to quickly identify the best hydrogenation conditions.

Our production capabilities include 2 x 1,500 L;  3,000 L; 2 x 6,000 L and 8,000 L reactors for hydrogenation reactions at up to 20 bar.

Halogenation reactions

We are equipped with extensive capabilities forbromination and chlorination reactions. We can use up to 10 MT of bromine in our 6,000 L and 4,000 L dedicated reaction vessel.

We are also experts in using Cl2,  PCl5, POCl3 and SOCl2 to produce tons of chlorinated compounds in our 4,000 L vessel dedicated to chlorination reactions.

Thanks to these large-scale capabilities, we manufacture various organic halides that can be used as starting material for the other key reactions we master, such as organometallic chemistry, transition metal-catalysed reactions, etc. 
More information on biocatalysis.

Organometallic chemistry

We have extensive experience in producing and using several organometallic compounds from kilogram to multi-ton scale.

Our ability to handle diborane from kilogram to multi-ton scale gives us access to several organoboranes (including chiral organoboranes), that can be used in many reactions. More information on organoborane chemistry.

Thanks to our know-how and capabilities in cryogenic reactions, we are able to manufacture large amounts of organolithium reagents.

Our expertise also includes the manufacture of organomagnesium, organotitanium and organosilicon compounds.

Heterocyclic chemistry

Thanks to our know-how and capabilities in hydrazineazidediazomethane and carbon disulfidechemistry, we are able to manufacture, at very large scale, a broad range of nitrogen- and sulfur-containing heterocycles such as pyrazoles, triazoles, thiadiazoles, pyridazines, tetrazoles, aziridines, etc.

Mitsunobu reactions

Mitsunobu reactions are very useful synthetic routes for transforming primary and secondary alcohols into a variety of functional groups with an inversion of configuration. At Novasep, we are able to perform Mitsunobu reactions at a very low cost, thanks to our mastery of hydrazine chemistry to produce azodicarboxylic acid derivatives in house in ton quantities.

More information on Mitsunobu reactions.

Fine chemistry Portfolio

  • Acetylation
  • Acylation
  • Acyl chloride chemistry
  • Alcoholysis
  • Aldol Additions / Condensations
  • Alkylation
  • Amination
  • Amidation
  • Arylation
  • Asymmetric synthesis
  • Azide Chemistry
  • Bayer-Villiger oxidation
  • Benzoylation
  • Biocatalysis
  • Borane Chemistry
  • Bromination
  • Buchwald reactions
  • Carbon Disulfide Chemistry
  • Carbonylation
  • Catalyzed C-C, C-N cross coupling
  • Chlorination
  • Claisen condensation
  • Condensation
  • Curtius Rearrangement
  • Cryogenic reactions
  • Cyanation
  • Cyclisation
  • Cyclopropanation
  • Dehydrogenation
  • Dehydrohalogenation
  • Dehydration
  • Decarboxylation
  • Diels Alder reaction
  • Dynamic kinetic resolution
  • Electrophilic subsititution
  • Epoxidation
  • Esterification
  • Etherification
  • Ethyl Diazoacetate Chemistry
  • Friedel-Crafts Reactions
  • Grignard reactions
  • Halide Exchange
  • Halogenation
  • Heterocyclic Chemistry
  • Hofmann rearrangement
  • Hydrazine Chemistry
  • Hydrogenation
  • Hydrolysis
  • Hydroxylation
  • Knoevenagel reaction
  • Indole Synthesis via Azide Route
  • Isocyanates chemistry
  • Isomerisation
  • Lithiation (BuLi, LDA,...)
  • Low temperature reaction
  • Mannich reaction
  • Meerwein Chlorosulphonation
  • Methylation by Diazomethane
  • Michael Addition
  • Mitsunobu Reaction
  • Nitration
  • Nitroalkane Chemistry
  • Nucleophilic substitution
  • Organometallic reactions
  • Oxidation
  • Ozonolysis
  • Peroxidation
  • Phosphorylation
  • Rearrangements
  • Reduction
  • Reductions with Metal Hydride (LiAlH4, NaBH4, )
  • Ritter Reaction
  • Sandmeyer reaction
  • Schmidt Rearrangement
  • Schotten-Baumann reactions
  • Sodium Amide Reactions
  • Saponification
  • Silylation
  • Sulfonation
  • Sulfoxidation
  • Swern Oxidation
  • Thiolation
  • Tosylation
  • Wittig reactions

 

Download our brochures for synthetic molecule manufacturing.

Contact us for any synthetic molecule manufacturing request.